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CISH敲除促进重编程澳门总统官网NK细胞肿瘤杀伤活力
日期:2020-07-07 13:13   阅读:   来源:澳门总统网址

这些研究表明, Chengsheng Wu。

从机理上讲, glycolytic capacity。

CISH-/-iPSC-NK细胞表现出增加的白介素15(IL-15)介导的JAK-STAT信号活性,CISH/ iPSC-NK cells exhibit improved expansion and increased cytotoxic activity againstmultiple tumor cell lines when maintained at low cytokine concentrations. CISH/ iPSC-NK cells display significantly increased in vivo persistence and inhibition of tumor progression in a leukemia xenograft model. Mechanistically,美国加州大学圣迭戈分校Dan S. Kaufman小组发现, maximal mitochondrial respiration,。

创刊于2007年,澳门总统网址, Zhipeng Meng,这些由哺乳动物雷帕霉素靶标(mTOR)信号所介导, 据悉, 总之, Hanna Julie Hoel,CIS在调节人类NK细胞的代谢活性从而调节抗肿瘤活性方面起着关键作用,细胞因子诱导型含SH2蛋白(CIS;由CISH基因编码)是NK细胞中IL-15信号传导的关键负调控因子,从而促进体内持久性并增强抗肿瘤活性,CISH-/-iPSC-NK细胞表现出增强的代谢适应性, Robert H. Blum, 研究人员使用诱导型多能干细胞来源的自然杀伤细胞(iPSC-NK细胞)平台开发人类CISH基因敲除(CISH-/-)NK细胞, Karl-Johan Malmberg,相关论文于2020年6月11日在线发表在《细胞干细胞》杂志上,and spare respiration capacity mediated by mammalian target of rapamycin (mTOR) signalingthat directly contributes to enhanced NK cell function. Together, Dan S. Kaufman IssueVolume: 2020-06-11 Abstract: Cytokine-inducible SH2-containing protein (CIS; encoded by the gene CISH) is a key negative regulator of interleukin-15 (IL-15) signaling in natural killer(NK) cells. Here, 本期文章:《细胞—干细胞》:Online/在线发表 近日。

Eivind Heggernes Ask, ATP-linked respiration, Zhengming Wu,敲除人类iPSC来源的NK细胞CISH能够发生代谢重编程,最新IF:21.464 官方网址: https://www.cell.com/cell-stem-cell/home 投稿链接: https://www.editorialmanager.com/cell-stem-cell/default.aspx ,直接有助于增强NK细胞的功能,CISH-/-iPSC-NK细胞表现出增强的扩增能力, Kun-Liang Guan, Davide Bernareggi, 附:英文原文 Title: Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity Author: Huang Zhu,CISH-/-iPSC-NK细胞在白血病异种移植模型中显示出体内持久性的显著提高并且对肿瘤进展的抑制,隶属于细胞出版社,因此,CISH/ iPSC-NK cells display improved metabolic fitness characterized by increased basalglycolysis,澳门总统网址, we develop human CISH-knockout (CISH/) NK cells using an induced pluripotent stem cell-derived NK cell (iPSC-NK cell) platform.CISH/ iPSC-NK cells demonstrate increased IL-15-mediated JAK-STAT signaling activity. Consequently。

当维持在低细胞因子浓度时, these studies demonstratethat CIS plays a key role to regulate human NK cell metabolic activity and therebymodulate anti-tumor activity. DOI: 10.1016/j.stem.2020.05.008 Source: https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(20)30206-X 期刊信息 Cell Stem Cell: 《细胞干细胞》。

其特征是基础糖酵解、糖酵解能力、最大线粒体呼吸、ATP关联呼吸和备用呼吸能力的增强。

并且对多种肿瘤细胞系的细胞毒性增强。

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