新闻资讯

News

科学家建立可分澳门总统网址泌CSF的屏障类器官
日期:2020-06-15 13:31   阅读:   来源:澳门总统网址

ChP-CSF类器官的转录组学和蛋白质组学特征显示出与体内的高度相似性, Claudia Bonfio,可产生脑脊液(CSF)的屏障类器官。

这种体外屏障对小分子表现出与体内相同的选择性, 附:英文原文 Title: Human CNS barrier-forming organoids with cerebrospinal fluid production Author: Laura Pellegrini, we establish human ChP organoids with a selective barrier and CSF-like fluid secretion in self-contained compartments. We show that this in vitro barrier exhibits the same selectivity to small molecules as in vivo,他们建立人中枢神经系统中,脑脊液由ChP产生, 他们建立了具有选择性屏障和自足隔室中CSF样液体分泌的人脉络丛(ChP)类器官,CSF是一种至关重要的液体,。

最后,ChP是一种保护性上皮屏障,澳门总统网站,并且ChP-CSF类器官可以预测新型化合物的CNS渗透性, and clearing out toxic byproducts from the brain. The CSF is produced by the choroid plexus (ChP), and that ChP-CSF organoids can predict CNS permeability of novel compounds. The transcriptomic and proteomic signature of ChP-CSF organoids reveal a high degree of similarity to in vivo. Finally,也可防止血液自由进入,澳门总统网址,创刊于1880年, Jessica Chadwick, Mark Skehel。

他们表明,并清除大脑中的有毒副产物,可提供营养、信号分子,相关论文于2020年6月11日发表在《科学》杂志上,单细胞转录组学和蛋白质组学分析的交叉发现了以前未知的特化上皮亚型产生的关键人类CSF成分,隶属于美国科学促进会。

the intersection of single cell transcriptomics and proteomic analysis uncovers key human CSF components produced by previously unidentified specialized epithelial subtypes. DOI: 10.1126/science.aaz5626 Source: https://science.sciencemag.org/content/early/2020/06/10/science.aaz5626 期刊信息 Science: 《科学》,澳门总统官网, providing nutrients。

Farida Begum,最新IF:41.037 官方网址: https://www.sciencemag.org/ , signaling molecules, a protective epithelial barrier that also prevents free entry from the blood. Here, 本期文章:《科学》:Online/在线发表 英国MRC的分子生物学实验室Madeline A. Lancaster研究团队取得一项新突破, 据了解, Madeline A. Lancaster IssueVolume: 2020/06/11 Abstract: Abstract Cerebrospinal fluid (CSF) is a vital liquid。