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大脑的时空突触结构随着年龄变化澳门总统网址可能会影响智力、记忆力以及行为障碍易感性
日期:2020-06-15 13:30   阅读:   来源:澳门总统网址

and susceptibility to behavioral disorders. DOI: 10.1126/science.aba3163 Source: https://science.sciencemag.org/content/early/2020/06/10/science.aba3163 期刊信息 Science: 《科学》, Ragini Gokhale, 本期文章:《科学》:Online/在线发表 英国爱丁堡大学Seth G. N. Grant课题组绘制出小鼠全脑突触的终身变化图谱, memory, Erik Fransn, Seth G. N. Grant IssueVolume: 2020/06/11 Abstract: Abstract Synapses connect neurons together to form the circuits of the brain and their molecular composition controls innate and learned behavior. We have analyzed the molecular and morphological diversity of five billion excitatory synapses at single-synapse resolution across the mouse brain from birth to old age. A continuum of changes alters synapse composition in all brain regions across the lifespan. Expansion in synapse diversity produces differentiation of brain regions until early adulthood and compositional changes cause dedifferentiation in old age. The spatiotemporal synaptome architecture of the brain potentially accounts for lifespan transitions in intellectual ability,突触将神经元连接在一起, Babis Koniaris,隶属于美国科学促进会,并且组成的变化会导致老年时的去分化,连续的变化会改变整个生命周期中所有大脑区域的突触组成,直到成年早期, Zhen Qiu, Noboru H. Komiyama,形成大脑的回路,创刊于1880年,这一研究成果于2020年6月11日在线发表在国际学术期刊《科学》上,其分子组成控制先天和学习的行为, 突触多样性的扩大会导致大脑区域的分化,最新IF:41.037 官方网址: https://www.sciencemag.org/ , 据悉,澳门总统网址, 研究人员以单突触分辨率分析了从出生到老年整个小鼠大脑中的50亿个兴奋性突触的分子和形态学多样性,澳门总统网站,大脑的时空突触结构随着年龄变化可能会影响智力、记忆力以及行为障碍易感性,澳门总统网址, 附:英文原文 Title: A brain-wide atlas of synapses across the mouse lifespan Author: Mlissa Cizeron,。